Search on:
N-MYC PROTO-ONCOGENE PROTEIN
Descriptors Found:
1
Displaying:
1 .. 1
1 / 1
DeCS
Descriptor
English
:
N-Myc Proto-Oncogene Protein
Descriptor
Spanish
:
Proteína Proto-Oncogénica N-Myc
Descriptor
Portuguese
:
Proteína Proto-Oncogênica N-Myc
Synonyms
English
:
BHLHE37 Protein
Class E Basic Helix-Loop-Helix Protein 37
MYCN Protein
N-Myc Protein
NMYC Protein
Class E Basic Helix Loop Helix Protein 37
N Myc Protein
N Myc Proto Oncogene Protein
Proto-Oncogene Protein, N-Myc
Tree Number:
D12.776.260.103.500.625
D12.776.260.108.092.625
D12.776.624.664.700.158
D12.776.930.125.500.563
D12.776.930.127.092.625
Definition
English
:
A basic helix-loop-helix
leucine
zipper (bHLHZ) transcription factor and proto-oncogene protein that functions in cell
growth
and proliferation. In
mammals
, it is highly expressed in the brain during embryogenesis and is essential for brain development; it is not expressed in adult
tissues
. Amplification or overexpression of N-Myc occurs in at least 20% of tumors and is associated with a poor
prognosis
in cases of
NEUROBLASTOMA
; ALVEOLAR
RHABDOMYOSARCOMA
;
SMALL CELL LUNG CARCINOMA
; and neuroendocrine
prostate
cancer.
History Note
English
:
2017
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
56596
Unique Identifier:
D000071447
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS